Large HDs vs Smaller HDs

For a given Raid 5 pool size, let’s say 12TB, with any need for expansion being very unlikely, is there any advantage in making it from 3 X 4TB or 4 X 3TB or even 6 X 2TB? Leaving aside differences in $ per TB.

I’d be grateful for advice.

Current advice is very much against using Raid 5/6 in BTRFS for anything important until it’s fixed.

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